The effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF
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منابع مشابه
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility.
HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Müllerian defects by changing HOX gene expression. HOX genes are also essential regulators ...
متن کاملI-24: The Role of Interleukins, Integrins and Other Proteins in Recurrent Implantation Failure
Embryo implantation represents the most critical step of the reproductive process in many species. Inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. The cell adhesion molecule (CAM) such as integrins, cadherins, selectins and immunoglobulins intervene to ensure adhesiveness between the embryo and the endometrium. Some recent studies indicate th...
متن کاملO-31: Epigenetic Aberration of HOXA10 Gene in Human Endometrium throughout The Menstrual Cycle in Endometriosis
Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...
متن کاملEffect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window
BACKGROUND HOXA11 and HOXA10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. The expression of these genes is decreased in women with myomas. OBJECTIVE To determine whether myomectomy would reverse HOXA11 and HOXA10 expression, we evaluated the transcript levels of these genes in the endometria o...
متن کاملSemi-Quantitative Analysis of HOXA11, Leukemia Inhibitory Factor and Basic Transcriptional Element Binding Protein 1 mRNA Expression in the Mid-Secretory Endometrium of patients with endometriosis
Background: HOXA11 and leukemia inhibitory factor (LIF) and basic transcriptional element binding protein1 (BTEB1) are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. In this case-control study, the expression pattern of these mRNA was evaluated in patients with endometriosis at the time of implantatio...
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